Compare to Active Ingredient Excedrin Extra Strength Pain Reliever is for the temporary relief of minor aches and pains associated with headache, sinusitis, a cold, muscular aches, premenstrual cramps, Doctors call the enhanced pain relieving effect provided by products that contain caffeine in combination with acetaminophen and aspirin “caffeine adjuvancy”. And doctors believe that these non-prescription combination pain-relief products offer major advantages for headache sufferers. toothache, and for the minor pain from arthritis. Extra Strength Excedrin is a combination pain reliever that contains acetaminophen, aspirin and therapeutically active caffeine.Interestingly, caffeine is also an ingredient in many of the most frequently used prescription headache medications. Adults: 2 Excedrin tablets with water every 6 hours while symptoms persist, not to exceed 8 tablets in 24 hours, or as directed by a doctor. Children under 12 years of age: Consult a doctor.